Women, like men, have inner struggles and inhibitions, and that is their nature, it is part of who they are. If you try to fix your wife's inner struggles and inhibitions, you are trying to change her, and that means that you are not happy with who she is. In a sense you are saying that you don't like her, so it will backfire on you and she will become more unhappy.
For men, there is us and our problems, and they are two separate things, that is why we love to fix our problems. However with women, their inner struggles and inhibitions, is part of who they are, and they rather learn to live with themselves than deny who they are, because it is betraying themselves. Only your wife can choose to change who she is, and if and when she does, be there to support her in her endeavor.
If there is a tragedy that you both are facing, don't make light of it, and don't fake being happy. Just let it be what it is, and be comforting.